Lowndesboro is a town in Lowndes County, Alabama, United States. At the 2010 census the population was 115, down from 140 in 2000. It is part of the Montgomery Metropolitan Statistical Area. Although initially incorporated in 1856 by an act of the state legislature, it lapsed and was not reincorporated until 1962.As of the 2000 and 2010 U.S. Censuses, Lowndesboro, along with Benton, are the only two towns in Lowndes County with a white majority of residents. Both are the 6th and 7th smallest communities.